Apoptosis in MCF-7 breast cancer cells induced by S-alkenylmercaptocysteine (CySSR) species derived from Allium tissues in combination with sodium selenite
详细信息 查看全文
- 作者：Wei Zhanga ; Hang Xiaob ; Kirk L. Parkina ; klparkin@wisc.edu" class="auth_mail
- 关键词：ACSO ; S-alk(en)-yl cysteine sulfoxides ; CySSR ; cysteine&ndash ; thiosulfinate mixed disulfide conjugate ; CySSA ; S-allylmercaptocysteine (CAS# 2281-22-3) ; CySSPe ; S-1-propenylmercaptocysteine ; CySH ; cysteine ; CySS ; cystine ; ROS ; reactive oxygen species ; MTT ; 3-(4 ; 5-dimethylthiazol-2-yl)-2 ; 5-diphenyl tetrazolium bromide ; DTNB ; 5 ; 5&prime ; -dithiobis(2-nitrobenzoate) ; PARP ; poly ADP-ribose polymerase ; SSZ ; sulfasalazine ; Xc- ; cystine antiporter ; Trx ; thioredoxin ; Grx ; glutatredoxin ; RS-X ; organosulfur
- 刊名：Food and Chemical Toxicology
- 出版年：June 2014
- 年：2014
- 卷：68
- 期：Complete
- 页码：1-10
- 全文大小：1351 K
文摘
- •
S-Allylmercaptocysteines (CySSR) act synergistically with sodium selenite to mediate apoptosis in breast cancer cells.
- •
The major CySSRs derived from onion and garlic are similarly potent, but act preferentially on different cellular targets.
- •
The proposed mechanism is that cells import and reduce CySSR, then export thiols to reduce selenite to the cytotoxic H2Se.