Effector Regulatory T Cell Differentiation and Immune Homeostasis Depend on the Transcription Factor Myb

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• 作者：Sheila Dias¹ ; ² ; Angela D&rsquo ; Amico¹ ; Erika Cretney¹ ; ² ; Yang Liao¹ ; ² ; Julie Tellier¹ ; ² ; Christine Bruggeman¹ ; ⁵ ; Francisca F. Almeida¹ ; ² ; Jamie Leahy¹ ; Gabrielle T. Belz¹ ; ² ; Gordon K. Smyth¹ ; ³ ; Wei Shi¹ ; ⁴ ; Stephen L. Nutt¹ ; ² ; ⁶ ; ^{nutt@wehi.edu.au}
• 关键词：digital genomic footprint ; immune pathology ; Myb ; peripheral regulatory T cell ; regulatory T cell ; transcription Factor
• 刊名：Immunity
• 出版年：2017
• 出版时间：17 January 2017
• 年：2017
• 卷：46
• 期：1
• 页码：78-91
• 全文大小：5385 K
• 卷排序：46

文摘

Myb is specifically expressed in ICOS+ effector Treg cells Mice lacking Myb in Treg cells develop severe inflammatory disease Myb is essential for effector Treg cell differentiation of thymus-derived Treg cells Myb controls effector Treg cell proliferation