Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype
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- 作者：Natassia M. Vieira1 ; 2 ; 3 ; Ingegerd Elvers4 ; 5 ; Matthew S. Alexander1 ; 2 ; 6 ; Yuri B. Moreira7 ; Alal Eran2 ; Juliana P. Gomes3 ; Jamie L. Marshall1 ; 2 ; Elinor K. Karlsson4 ; 10 ; Sergio Verjovski-Almeida7 ; 8 ; Kerstin Lindblad-Toh4 ; 5 ; 11 ; Louis M. Kunkel1 ; 2 ; 9 ; 11 ; kunkel@enders.tch.harvard.edu" class="auth_mail" title="E-mail the corresponding author ; Mayana Zatz3 ; 11 ; mayazatz@usp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：DMD ; Jagged1 ; muscle ; dystrophin ; genetic modifier
- 刊名：Cell
- 出版年：2015
- 出版时间：19 November 2015
- 年：2015
- 卷：163
- 期：5
- 页码：1204-1213
- 全文大小：3230 K
文摘
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Escaper GRMD dogs show that a normal lifespan is possible without muscle dystrophin
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Jagged1, a Notch ligand, is upregulated in mildly affected dystrophin deficient dogs
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Jagged1 overexpression can rescue the phenotype of dystrophin deficient zebrafish