Evaluation of titanium dioxide nanocrystal-induced genotoxicity by the cytokinesis-block micronucleus assay and the Drosophila wing spot test
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- 作者：É ; rica de Melo Reisa ; Alexandre Azenha Alves de Rezendea ; Pollyanna Francielli de Oliveirab ; Heloiza Diniz Nicolellab ; Denise Crispim Tavaresb ; Anielle Christine Almeida Silvac ; Noelio Oliveira Dantasc ; Má ; rio Antô ; nio Spanó ; a ; maspano@ufu.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：In vitro ; In vivo ; Mutagenicity ; Nanotoxicology ; Titania ; Titanium (IV) oxide
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：309-319
- 全文大小：1701 K
文摘
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Anatase and rutile TiO2 NCs induce mutagenic activity in Drosophila melanogaster.
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Anatase and rutile TiO2 NCs are mutagenic only in the HB crosses of SMART assay.
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There are negative correlation between size and mutagenicity of anatase TiO2 NCs.
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Only the smallest size of anatase TiO2 NCs induces micronucleus formation.