Fractality and entropic scaling in the chromosomal distribution of conserved noncoding elements in the human genome
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- 作者：Dimitris Polychronopoulosa ; 1 ; Labrini Athanasopouloub ; Yannis Almirantisa ; yalmir@bio.demokritos.gr" class="auth_mail" title="E-mail the corresponding author
- 关键词：CNEs ; conserved noncoding elements ; E ; extent of linearity in semi-logarithmic scale ; FrL ; Fractality-related Linearity ; GRBs ; Genomic Regulatory Blocks ; PCSs ; Protein Coding Segments ; SD ; segmental duplication ; TEs ; Transposable Elements ; UCEs ; UCNEs ; ultraconserved elements
- 刊名：Gene
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：584
- 期：2
- 页码：148-160
- 全文大小：1820 K
文摘
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The chromosomal distribution of conserved noncoding elements (CNEs) is analyzed.
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CNEs are scattered across chromosomes with intriguing fractal-like patterns.
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Box-counting and scaling of block-entropy quantify the degree of fractality.
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Pronounced fractality is evident in extremely conserved or ancient CNEs.
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An evolutionary model is proposed which accounts for the observed fractality traits.