Targeted disruption of the orphan receptor Gpr151 does not alter pain-related behaviour despite a strong induction in dorsal root ganglion expression in a model of neuropathic pain
Gpr151 is an orphan GPCR of unknown function. RT-PCR demonstrated a 50-fold increase in Gpr151 mRNA in the DRG 7 days after a nerve injury model of neuropathic pain. Acute, inflammatory and neuropathic pain behaviours were unchanged between Gpr151 mutant mice and wild-type controls. Galanin did not induce calcium signalling responses in ND7/23 cells transfected with Gpr151.