Galanin contributes to monoaminergic dysfunction and to dependent neurobehavioral comorbidities of epilepsy

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• 作者：Jesus-Servando Medel-Matus^a ; Don Shin^a ; Raman Sankar^a ; ^b ; ^c ; Andrey Mazarati^a ; ^c ; ^{mazarati@ucla.edu}
• 关键词：Epilepsy ; Comorbidity ; Depression ; Attention deficit/hyperactivity disorder ; Serotonin ; Norepinephrine ; Galanin ; Raphe nucleus ; Locus coeruleus ; Prefrontal cortex
• 刊名：Experimental Neurology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：289
• 期：Complete
• 页码：64-72
• 全文大小：976 K
• 卷排序：289

文摘

Rats with chronic epilepsy develop depressive-like or impulsive-like behaviors. Suppressed serotonin (5-HT) release from raphe nucleus (RN) underlies depression. Suppressed norepinephrine release from locus coeruleus (LC) underlies impulsivity. Blockade of RN GalR1, but not GalR2 receptor improves 5-HT release and depression. Blockade of LC GalR1, but not GalR2 receptor improves NE release and impulsivity.