Surface-enhanced Raman spectroscopic study of DNA and 6-mercapto-1-hexanol interactions using large area mapping

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• 作者：Kasper Bayer Frø ; hling^a ; ^{kasper.frohling@gmail.com" class="auth_mail" title="E-mail the corresponding author} ; Tommy Sonne Alstrø ; m^b ; Michael Bache^a ; Michael Stenbæ ; k Schmidt^a ; Mikkel Nø ; rgaard Schmidt^b ; Jan Larsen^b ; Mogens Havsteen Jakobsen^a ; Anja Boisen^a
• 关键词：SERS ; Area mapping ; DNA ; 6-Mercapto-1-hexanol ; Thiol ; Gold ; Peak-fitting
• 刊名：Vibrational Spectroscopy
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：86
• 期：Complete
• 页码：331-336
• 全文大小：1037 K

文摘

The emergence of 2D SERS substrates with large areas of hot spots has enabled data to be gathered at large scale. This work presents a statistical tool for analysing large amounts of SERS data by utilizing a peak-fitting model in a specific spectral range. By analysing the distributions of Raman intensities and peak positions it is possible to directly inspect the interplay between DNA and 6-mercapto-1-hexanol on gold covered nanopillars. It is demonstrated that optimised functionalization parameters can be extracted from the Raman spectra directly. Using the peak-fitting approach it is possible to avoid miss-interpretation of intensity histograms, where contamination might contribute with an enhanced background and not a peak.