Alternative end-joining repair pathways are the ultimate backup for abrogated classical non-homologous end-joining and homologous recombination repair: Implications for the formation of chromosome translocations
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- 作者：George Iliakis ; Georg.Iliakis@uk-essen.de" class="auth_mail" title="E-mail the corresponding author ; Tamara Murmann ; Aashish Soni
- 关键词：DNA double strand breaks ; Ionizing radiation ; Homologous recombination repair ; Alternative end-joining ; Non-homologous end-joining ; Chromosome translocations
- 刊名：Mutation Research/Genetic Toxicology and Environmental Mutagenesis
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：793
- 期：Complete
- 页码：166-175
- 全文大小：1433 K
文摘
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Ionizing radiation induces a severe form of DNA damage: double strand break (DSB).
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DSBs in higher eukaryotes are processed by HRR, c-NHEJ and alt-EJ.
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c-NHEJ and alt-EJ are implicated in the formation of chromosome translocations.
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We develop the view that alt-EJ operates as backup to abrogated HRR and c-NHEJ.
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We discuss that alt-EJ has major contribution to chromosome translocation formation.