Extensive macrophage accumulation in young and old Niemann-Pick C1 model mice involves the alternative, M2, activation pathway and inhibition of macrophage apoptosis
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- 作者：Gail Deutscha ; Akshay Muralidharb ; Ellen Leb ; Ivan A. Borbonb ; Robert P. Ericksonb ; c ; erickson@peds.arizona.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：BAL ; bronchoalveolar lavage ; ELISA ; enzyme-liked immunosorbent assay ; GFAP ; glial fibrillary acid protein ; GM-CSF ; granulocyte macrophage colony-stimulating factor ; H & E ; hematoxylin and eosin ; HPBCD ; hydroxypropyl-beta-cyclodextrin ; NPC1 ; Niemann&ndash ; Pick C 1 ; NPC2 ; Niemann&ndash ; Pick C 2 ; NSE ; neuron-specific enolase ; PAS ; periodic acid Schiff's ; PBS ; phosphate-buffered saline ; S1P ; Sphingosine-1-phosphate ; SEM ; standard error of the mean ; TUNEL ; terminal deoxynucleotidyl transferase-mediat
- 刊名：Gene
- 出版年：2016
- 出版时间：10 March 2016
- 年：2016
- 卷：578
- 期：2
- 页码：242-250
- 全文大小：2254 K
文摘
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Cholesterol-filled foamy macrophages massively accumulate in Npc1−/− lungs.
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Two markers of alternative macrophage activation show that this pathway is involved.
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Two mitotic markers show relatively low levels of cell division.
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TUNEL staining showed low levels of apoptosis in these macrophages.
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Thus, large number of macrophages accumulate and die slowly.