A high throughput passive dosing format for the Fish Embryo Acute Toxicity test
详细信息 查看全文
- 作者：Lucia Vergauwena ; lucia.vergauwen@uantwerpen.be" class="auth_mail" title="E-mail the corresponding author ; Stine N. Schmidtb ; Evelyn Stinckensa ; Walid Mahoc ; Ronny Blustd ; Philipp Mayerb ; Adrian Covacic ; Dries Knapena
- 关键词：AhR ; aryl hydrocarbon receptor ; AOP ; adverse outcome pathway ; C ; (regular) control ; CBR(LIP)50 ; (lipid normalized) critical body residue ; Ea50 ; effective chemical activity ; EBR(LIP)50 ; (lipid normalized) effective body residue ; ED50 ; effective dose ; EI ; electron ionization mode ; EURL ECVAM ; European Union Reference Laboratory for alternatives to animal testing &ndash ; European Centre for the Validation of Alternative Methods ; FET ; Fish Embryo Acute Toxicity ; HOC ; hydrophobic organic compound ; Hp
- 刊名：Chemosphere
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：139
- 期：Complete
- 页码：9-17
- 全文大小：1537 K
文摘
- •
Silicone O-rings are a practical means of applying passive dosing in the FET test.
- •
Controlled exposure conditions for phenanthrene were achieved.
- •
We report (sublethal) effect values in terms of chemical activity and body residue.
- •
Effect values were within ranges expected for baseline toxicity.
- •
Phenanthrene caused impaired swim bladder inflation and reduced motility.