Successful percutaneous coronary angioplasty in a patient with anomalous origin of the right coronary artery from the left anterior descending artery
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- 作者：Arslan Ocal ; Hakan Kilci ; Fatih Altunkas ; Mustafa M. Tumuklu
- 关键词：Coronary artery anomaly ; Stenting ; Left anterior descending artery
- 刊名：International Journal of Cardiology
- 出版年：2008
- 出版时间：4 July 2008
- 年：2008
- 卷：127
- 期：2
- 页码：e42-e44
- 全文大小：306 K
文摘
The mechanisms involved in both local and systemic effects of Loxosceles intermedia (brown spider) venom (LIV) are still poorly understood. We show using rats treated with Evans blue dye (50 mg/kg, i.v.) that small doses of the LIV (0.1, 0.3, 1 and 3 μg/site) dose-dependently increase the vascular permeability in rats, an effect unchanged by indomethacin (5 mg/kg, i.p.), atropine (1 mg/kg, i.p.), HOE-140 (2 mg/kg, s.c.) or SR140333 (0.3 mg/kg, i.p.), but fully avoided by promethazine (15 mg/kg, i.p.), methysergide (2 mg/kg, i.p.) and compound 48/80 (3 mg/kg/day for 3 days). Addition of cumulative concentrations of LIV (0.1–5 μg) in phenylephrine-contracted aortic rings resulted in a partial (![]()
40 % ) and endothelium-dependent relaxation, inhibited by the nitric oxide synthase inhibitors l-NAME (10 μM) and l-NMMA (1 mM), and the guanylate cyclase inhibitors methylene blue (100 μM) and ODQ (10 μM). LIV-induced relaxation was abolished by compound 48/80 (10 μM) and pyrilamine (a selective histamine H1 receptor antagonist; 100 μM), but not by atropine (1 μM) and indomethacin (10 μM). Our results disclose that LIV increases vascular permeability and induces vascular relaxation. These effects occur due to its ability to degranulate mast cells and release mediators such as histamine and serotonine.