Effect of aluminium on migration of oestrogen unresponsive MDA-MB-231 human breast cancer cells in culture
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- 作者：Ayse Bakir ; Philippa D. Darbre ; p.d.darbre@reading.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aluminium ; Antiperspirant ; Breast cancer ; Cell invasion ; Cell migration ; MDA-MB-231 cells ; Matrix metalloproteinase ; xCELLigence
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：152
- 期：Complete
- 页码：180-185
- 全文大小：726 K
文摘
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MDA-MB-231 cells exposed > 20 weeks to 10&100 μM Al chloride/chlorohydrate.
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Al exposure increased motility by live cell imaging & xCELLigence.
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Al exposure increased invasion through matrigel.
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Al exposure increased secretion of active MMP9.
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Al exposure increased intracellular levels of activated MMP14.