Effects of aluminium chloride and aluminium chlorohydrate on DNA repair in MCF10A immortalised non-transformed human breast epithelial cells
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- 作者：A. Farasani ; P.D. Darbre ; p.d.darbre@reading.ac.uk" class="auth_mail" title="E-mail the corresponding author
- 关键词：Aluminium chloride ; Aluminium chlorohydrate ; Antiperspirant ; BRCA1 ; BRCA2 ; Breast cancer ; DNA repair ; MCF10A cells
- 刊名：Journal of Inorganic Biochemistry
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：152
- 期：Complete
- 页码：186-189
- 全文大小：340 K
文摘
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MCF10A cells exposed 20 weeks to 100 μM Al chloride/chlorohydrate
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Al exposure reduced levels of BRCA1 mRNA and BRCA1 protein.
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Al exposure reduced mRNA levels for other DNA repair genes (BRCA2, CHK1, CHK2, Rad51, ATR).