Preparation and optimization of a drug delivery system based on berberine chloride-immobilized MgAl hydrotalcite
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- 作者：Mohamed Amine Djebbia ; b ; mohamed.djebbi@etu.univ-lyon1.fr" class="auth_mail" title="E-mail the corresponding author ; med-djebbi@hotmail.fr" class="auth_mail" title="E-mail the corresponding author ; Zaineb Bouaziza ; Alae Elabedc ; Moulay Sadikic ; Soumya Elabedc ; Philippe Namourb ; d ; Nicole Jaffrezic-Renaultb ; Abdesslem Ben Haj Amaraa
- 关键词：Aluminum chloride hexahydrate (PubChem CID ; 24564) ; Aluminum nitrate nanohydrate (PubChem CID ; 24567) ; Berberine Chloride (PubChem CID ; 12456) ; Magnesium chloride hexahydrate (PubChem CID ; 24644) ; Magnesium nitrate hexahydrate (PubChem CID ; 202877) ; Phosphate-buffered saline (PubChem CID ; 24978514) ; Sodium hydroxide (PubChem CID ; 14798) ; Urea (PubChem CID ; 1176)
- 刊名：International Journal of Pharmaceutics
- 出版年：2016
- 出版时间：15 June 2016
- 年：2016
- 卷：506
- 期：1-2
- 页码：438-448
- 全文大小：1447 K
文摘
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Berberine chloride was immobilized into MgAl LDH by ion-exchange and co-precipitation methods.
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The two methods favor different adsorption efficiency with slightly different physico-chemical properties.
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Berberine chloride-MgAl LDH biohybrids have the potential to be used as a controlled release formulation.
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Anti-bacterial assay for berberine chloride-MgAl indicates the efficacy of biohybrid as an efficient drug carrier.