Flow injection photometric determination of NaCl, KCl and glucose in injectable drugs exploiting Schlieren signals

详细信息    查看全文

• 作者：Paulo Henrique Gonç ; alves Dias Diniz ; Karla Danielle Tavares de Melo ; Yebá ; Ngoamã ; n Martins Fagundes ; Adriano de Araujo Gomes ; Elaine Cristina Lima do Nascimento ; Sé ; rgio Ricardo Bezerra dos Santos ; Luciano Farias de Almeida ; Má ; rio Cé ; sar Ugulino de Araú ; jo ; ^{laqa@quimica.ufpb.br}
• 关键词：Schlieren effect ; FIA ; Injectable drugs ; PLS
• 刊名：Journal of Pharmaceutical and Biomedical Analysis
• 出版年：2012
• 出版时间：25 March, 2012
• 年：2012
• 卷：62
• 期：Complete
• 页码：172-176
• 全文大小：330 K

文摘

A flow injection photometric system that exploits Schlieren signals for analytical measurement is described. The system was designed to be used as a new strategy for determining the contents of sodium chloride, potassium chloride and glucose, each respectively in injectable drugs. The proposed methodology was based on the difference between the refractive indices of the sample zone and of the carrier stream. With this perspective, a lab-made photometer based on LED-phototransistor technology was employed as a detection system to investigate the different analytical profiles related to the Schlieren effect in low flow rate conditions. The parameters of the flow system, such as flow-rate, optical path length, and sampling loop, were adjusted in order to obtain suitable Schlieren profiles for the measurements. Data evaluation was performed with the application of partial least squares regression (PLS-1). The obtained results demonstrated the predictive ability of the constructed PLS models, and the predicted concentration values were in agreement with the reference values, with a 95 % confidence level.