Synthesis, characterization and anticancer properties of (salicylaldiminato)platinum(II) complexes
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- 作者：Alyssa E. Pattersona ; Jessica J. Millera ; Brittany A. Milesa ; Erin L. Stewarta ; José ; e-Marie E.J. Melansona ; Christopher M. Vogelsa ; Amanda M. Cockshutta ; Andreas Deckenb ; Pier Morin Jr.c ; ; Stephen A. Westcotta ; swestcott@mta.ca" class="auth_mail
- 关键词：Cancer ; Glioma ; Platinum ; Salicylaldimine ; Schiff base
- 刊名：Inorganica Chimica Acta
- 出版年：1 May 2014
- 年：2014
- 卷：415
- 期：Complete
- 页码：88-94
- 全文大小：765 K
文摘
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Six novel bis Schiff base platinum complexes have been prepared.
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Six organometallic mono Schiff base platinum complexes also prepared.
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Solubility problems with the bis Schiff base complexes complicated biotesting.
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Addition of cyclooctene group increases solubility to organometallic complexes.
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All new species showed cytotoxic activities against glioma cell lines.