FAM13A polymorphism as a prognostic factor in patients with idiopathic pulmonary fibrosis

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• 作者：Chihiro Hirano^a ; ^{cyamaoka62@hiroshoma-u.ac.jp} ; Shinichiro Ohshimo^a ; ^b ; ; Yasushi Horimasu^a ; ^{yasushi17@hiroshima-u.ac.jp} ; Hiroshi Iwamoto^a ; ^{hir@hiroshima-u.ac.jp} ; Kazunori Fujitaka^a ; ^{fujikazu@hiroshima-u.ac.jp} ; Hironobu Hamada^c ; ^{hirohamada@hiroshima-u.ac.jp} ; Noboru Hattori^a ; ^{nhattori@hiroshima-u.ac.jp} ; Nobuaki Shime^b ; ^{nshime@hiroshima-u.ac.jp} ; Francesco Bonella^d ; ^{francesco.bonella@ruhrlandklinik.uk-essen.de} ; Josune Guzman^e ; ^{josune.guzman@ruhr-uni-bochum.de} ; Ulrich Costabel^d ; ^{ulrich.costabel@ruhrlandklinik.uk-essen.de} ; Nobuoki Kohno^a ; ^f ; ^{nokohno@hiroshima-u.ac.jp}
• 关键词：Idiopathic pulmonary fibrosis ; Single nucleotide polymorphism ; Family with sequence similarity 13 ; Member A (FAM13A)
• 刊名：Respiratory Medicine
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：123
• 期：Complete
• 页码：105-109
• 全文大小：376 K
• 卷排序：123

文摘

The minor G allele of FAM13A is associated with the susceptibility to IPF. The major T allele of FAM13A is associated with impaired pulmonary function. The major T allele of FAM13A is a risk factor for poor overall survival in IPF.