Inhibitory effects of Dai-saiko-to (Da-Chai-Hu-Tang) on the progression of atherosclerotic lesions in Kurosawa and Kusanagi-hypercholesterolemic rabbits

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• 作者：Iizuka ; Akira ; T. Iijima ; Osamu ; Yoshie ; Fumihiko ; Makino ; Bunsho ; Amagaya ; Sakae ; Komatsu ; Yasuhiro ; et. al.
• 关键词：Dai-saiko-to ; Atherosclerosis ; Antioxidation ; KHC rabbits
• 刊名：Journal of Ethnopharmacology
• 出版年：1998
• 出版时间：December, 1998
• 年：1998
• 卷：63
• 期：3
• 页码：209-218
• 全文大小：676 K

文摘

The inhibitory effects of the traditional herbal medicine Dai-saiko-to (Da-Chai-Hu-Tang) on the progression of the atherosclerotic lesions were studied using the spontaneous familial hypercholesterolemia (FH) model, Kurosawa and Kusanagi-hypercholesterolemic (KHC) rabbits. Changes in blood chemistry, pathology and low-density lipoprotein (LDL) oxidation were measured in a control group and a Dai-saiko-to-treated group. In the control group, the area of atheromatous plaques of the aorta progressed between week 12 (29.1 % ) and 26 (51.5 % ). This progression of atherosclerotic lesions did not happen in the Dai-saiko-to-treated group between week 12 (26 % ) and 26 (27.4 % ). Antioxidative effects on LDL were seen in the Dai-saiko-to-treated group in weeks 16 and 18. Dai-saiko-to did not improve the hypercholesterolemia in the KHC rabbits. These results suggest that Dai-saiko-to has inhibitory effects on the development of atheromatous plaque formation in spontaneous FH model rabbits. It is possible that the antioxidative effects of Dai-saiko-to on LDL led to the beneficial effects observed in this study.