Improving effects of the extracts from Eugenia uniflora on hyperglycemia and hypertriglyceridemia in mice

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• 作者：Arai ; Ichiro ; Amagaya ; Sakae ; Komatsu ; Yasuhiro ; Okada ; Minoru ; Hayashi ; Toshimitsu ; Kasai ; Mie ; et. al.
• 关键词：Eugenia uniflora ; Glucose tolerance test ; Sucrose tolerance test ; Corn oil tolerance test ; α ; -Glucosidase ; Pancreatic lipase
• 刊名：Journal of Ethnopharmacology
• 出版年：1999
• 出版时间：December 15, 1999
• 年：1999
• 卷：68
• 期：1-3
• 页码：307-314
• 全文大小：158 K

文摘

EtOH (70 % ) extracts from the leaves of Eugenia uniflora were separated into six fractions with different polarity and molecular size, i.e. NP-1–NP-6. In an oral glucose tolerance test, NP-1 and 4 inhibited the increase in plasma glucose level. However, in an intraperitoneal glucose tolerance test, such an inhibitory effect was not seen. Thus, the effects of NP-1 and 4 were apparently due to the inhibition of glucose absorption from the intestine. In a sucrose tolerance test, all fractions inhibited the increase in plasma glucose level. In an oral corn oil tolerance test, NP-3 and 4 showed an inhibitory effect on the increase in plasma triglycerides level. On the other hand, NP-3, 4, 5 and 6 inhibited maltase and sucrase activities and all fractions except for NP-1 showed an inhibitory effect on lipase activity dose-dependently. The inhibition of the increase in plasma glucose level by NP-3, 4, 5 and 6 in the oral sucrose tolerance test and the inhibition of the increase in plasma triglycerides by NP-3 and 4 in the oral corn oil tolerance test were apparently due to the inhibition of the decomposition of carbohydrates and fats in the intestine, respectively.