Sodium butyrate has an antimanic effect and protects the brain against oxidative stress in an animal model of mania induced by ouabain
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- 作者：Samira S. Valvassoria ; samiravalvassori@unesc.net" class="auth_mail" title="E-mail the corresponding author ; Gustavo C. Dal-Ponta ; Amanda V. Steckerta ; Roger B. Varelaa ; Jé ; ssica Lopes-Borgesa ; Edemilson Mariota ; Wilson R. Resendea ; Camila O. Arenta ; André ; F. Carvalhob ; Joã ; o Quevedoa ; c ; d ; e
- 关键词：Bipolar disorder ; Ouabain ; Sodium butyrate ; Oxidative stress
- 刊名：Psychiatry Research
- 出版年：2016
- 出版时间：30 January 2016
- 年：2016
- 卷：235
- 期：Complete
- 页码：154-159
- 全文大小：2409 K
文摘
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Butyrate reverses the hyperactivity induced by ouabain, indicating an antimanic effect.
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Ouabain increased TBARS and carbonyl content in frontal cortex and hippocampus of rats.
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Butyrate treatment reversed the lipid and protein peroxidation in both cerebral areas.
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Ouabain increased antioxidant enzymes activity in both cerebral areas of rats.
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Butyrate treatment reverses ouabain-induced catalase alteration in brains of rats.