Altered S-nitrosothiol homeostasis provides a survival advantage to breast cancer cells in HER2 tumors and reduces their sensitivity to trastuzumab
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- 作者：Amanda Cañ ; asa ; b ; amandacanasrodriguez@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Laura M. Ló ; pez-Sá ; ncheza ; b ; lmlopezsanchez@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Jon Peñ ; arandoa ; b ; jon_aries80@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Araceli Valverdea ; b ; aracelivalverdeestepa@hotmail.es" class="auth_mail" title="E-mail the corresponding author ; Francisco Condea ; b ; fmcp@usal.es" class="auth_mail" title="E-mail the corresponding author ; Vanessa Herná ; ndeza ; b ; vanessa-septiembre@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Elena Fuentesc ; elena.fuentes.sspa@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author ; Chary Ló ; pez-Pedrerad ; rosario.lopez.exts@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author ; Juan R. de la Haba-Rodrí ; gueza ; b ; juahaba@gmail.com" class="auth_mail" title="E-mail the corresponding author ; Enrique Arandaa ; b ; earandaa@seom.org" class="auth_mail" title="E-mail the corresponding author ; Antonio Rodrí ; guez-Arizaa ; b ; antonio.rodriguez.exts@juntadeandalucia.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：Apoptosis ; Breast cancer ; S-nitrosoglutathione reductase ; HER2/neu ; Nitric oxide ; S-nitrosylation
- 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：1862
- 期：4
- 页码：601-610
- 全文大小：1562 K
文摘
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Response of breast cancer cells to anti-HER2 therapy is suppressed when S-nitrosothiol homeostasis is impaired.
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Altered S-nitrosothiol homeostasis constitutes a mechanism of resistance to anti-HER2 therapy in breast cancer.
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Mechanisms controlling S-nitrosothiol homeostasis may be important prognostic and predictive factors in breast cancer.