Low dose X-irradiation mitigates diazepam induced depression in rat brain
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- 作者：Amandeep Kaur ; Neha Singla nehasbph@gmail.com" class="auth_mail" title="E-mail the corresponding author ; D.K. Dhawan ; dhawan@pu.ac.in" class="auth_mail" title="E-mail the corresponding author
- 关键词：Depression ; Diazepam ; Low dose radiation ; Behavior ; Antioxidants ; Apoptosis ; Brain
- 刊名：Regulatory Toxicology and Pharmacology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：80
- 期：Complete
- 页码：82-90
- 全文大小：1512 K
文摘
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The present study shows the role of X-rays during diazepam induced depression.
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Low dose X-rays was able to mitigate diazepam induced oxidative stress.
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Diazepam decreased neurotransmitters levels which were increased on X-irradiation.
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Diazepam altered neurobehavior indices which were restored on X-rays treatment.