S-1-Propenylcysteine promotes the differentiation of B cells into IgA-producing cells by the induction of Erk1/2-dependent Xbp1 expression in Peyer's patches
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- 作者：Jun-ichiro Suzuki ; Ph.D. ; suzuki_j@wakunaga.co.jp" class="auth_mail" title="E-mail the corresponding author ; Takako Yamaguchi ; M.S. ; Toshiaki Matsutomo ; M.S. ; Hirotaka Amano ; M.S. ; Naoaki Morihara ; Ph.D. ; Yukihiro Kodera ; Ph.D.
- 关键词：Sulfur-containing amino acids ; Intestinal immune response ; Immunoglobulin A ; Plasma cell differentiation ; Transcription factor
- 刊名：Nutrition
- 出版年：2016
- 出版时间：July-August 2016
- 年：2016
- 卷：32
- 期：7-8
- 页码：884-889
- 全文大小：1048 K
文摘
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S-1-Propenylcysteine (S1PC) enhanced immunoglobulin (Ig)A production in vitro and in vivo.
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S1PC increased IgA-producing cells in Peyer's patches.
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S1PC induced Erk1/2-mediated Pax5 degradation.
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S1PC increased the expression of Xbp1 mRNA in Peyer's Patches.