Structure–activity relationship studies of small-molecule inhibitors of Wnt response
详细信息 查看全文
- 作者：Jianming Lu ; Zhiqiang Ma ; Jen-Chieh Hsieh ; Chih-Wei Fan ; Baozhi Chen ; Jamie C. Longgood ; Noelle S. Williams ; James F. Amatruda ; Lawrence Lum ; Chuo Chen
- 关键词：Wnt ; Inhibitor ; SAR ; IWR
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2009
- 出版时间：15 July 2009
- 年：2009
- 卷：19
- 期：14
- 页码：3825-3827
- 全文大小：380 K
文摘
Suppression of oncogenic Wnt-mediated signaling holds promise as an anti-cancer therapeutic strategy. We previously reported a novel class of small molecules (IWR-1/2, inhibitors of Wnt response) that antagonize Wnt signaling by stabilizing the Axin destruction complex. Herein, we present the results of structure-activity relationship studies of these compounds.