Nutrient-sensing mTORC1: Integration of metabolic and autophagic signals
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- 作者：Valerie P. Tan ; Shigeki Miyamoto ; smiyamoto@ucsd.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：2-DG ; 2-deoxy-D-glucose ; α KG ; α-ketoglutarate ; AMBRA1 ; autophagy/beclin 1 regulator 1 ; AMPK ; AMP-activated protein kinase ; Arf1 ; adenosine diphosphate ribosylation factor-1 ; Atg ; autophagy-related ; ATM ; ataxia-telangiectasia mutated kinase ; Bcl-2 ; B-cell lymphoma 2 ; Bnip3 ; BCL2/adenovirus E1B 19 ; kDa interacting protein 3 ; Bnip3L (NIX) ; BCL2/adenovirus E1B 19 ; kDa interacting protein 3-like ; DAPK2 ; death-associated protein kinase 2 ; ERK ; Extracellular signal-regulated kinase ; FFAs ; free
- 刊名：Journal of Molecular and Cellular Cardiology
- 出版年：2016
- 出版时间：June 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：31-41
- 全文大小：993 K
文摘
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Autophagy is important for maintaining cardiac homeostasis.
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mTORC1 plays a major role in regulating cellular growth and metabolism and inhibits autophagy
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mTORC1 serves as a convergent point in nutrient-sensing pathways.