In vitro testing of new somatostatin analogs on pituitary tumor cells

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• 作者：Maria Chiara Zatelli ; Maria Rosaria Ambrosio ; Marta Bondanelli ; Ettore C. degli Uberti
• 关键词：Pituitary ; Somatostatin ; Somatostatin analogs ; Somatostatin receptors
• 刊名：Molecular and Cellular Endocrinology
• 出版年：2008
• 出版时间：14 May 2008
• 年：2008
• 卷：286
• 期：1-2
• 页码：187-191
• 全文大小：116 K

文摘

Somatostatin has been discovered as a somatotroph release inhibitory factor (SRIF), and, indeed, it has been demonstrated that SRIF and its analogs can inhibit pituitary tumor hormone secretion and control neoplastic bulk. Several in vitro studies have contributed to the current knowledge of the mechanisms by which SRIF and its analogs may influence pituitary adenomas, opening the way to new possible therapeutic strategies.