Central role for marginal zone B cells in an animal model of Sjogren's syndrome
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- 作者：Long Shena ; 1 ; Chun Gaoa ; b ; 1 ; Lakshmanan Sureshc ; Zhenhua Xianb ; Nannan Songb ; Lee D. Chavesa ; Meixing Yua ; Julian L. Ambrus Jr.a ; jambrus@buffalo.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Clinical Immunology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：168
- 期：Complete
- 页码：30-36
- 全文大小：2005 K
文摘
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This manuscript shows for the first time the critical requirement of marginal zone B cells for the development of Sjogren's syndrome in IL-14 transgenic mice.
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MZB are critical for development of Sjogren's syndrome in IL14aTG mice.
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MZB produce lymphotoxin that is involved in the pathophysiology of Sjogren's syndrome.