CXCR4 antagonist AMD3100 reverses the neurogenesis promoted by enriched environment and suppresses long-term seizure activity in adult rats of temporal lobe epilepsy

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• 作者：Zhike Zhou^a ; ¹ ; Tingting Liu^b ; ¹ ; Xiaoyu Sun^b ; Xiaopeng Mu^c ; Gang Zhu^d ; Ting Xiao^e ; Mei Zhao^f ; Chuansheng Zhao^c ; ^{cszhao@mail.cmu.edu.cn}
• 关键词：Temporal lobe epilepsy ; Enriched environment ; Neurogenesis ; Stromal cell-derived factor-1
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：30 March 2017
• 年：2017
• 卷：322
• 期：part_PA
• 页码：83-91
• 全文大小：3105 K
• 卷排序：322

文摘

EE increased hippocampal neurogenesis, improving cognitive impairments and decreasing long-term seizure activity after TLE. These effects of EE might be mediated through SDF-1/CXCR4 pathway. AMD3100 reversed the effect of EE on neurogenesis, but it did not abolish the cognitive improvement induced by EE after TLE. EE combined with AMD3100 has the ability to suppress long-term seizure activity significantly.