Nanoformulation of synergistic TLR ligands to enhance vaccination against Entamoeba histolytica

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• 作者：Mayuresh M. Abhyankar^a ; ^{mma3a@virginia.edu} ; Zannatun Noor^a ; Mark A. Tomai^b ; James Elvecrog^b ; Christopher B. Fox^c ; ^d ; William A. Petri Jr.^a ; ^{wap3g@virginia.edu}
• 关键词：Liposome ; Vaccine ; Immune response ; Amebiasis ; Entamoeba
• 刊名：Vaccine
• 出版年：2017
• 出版时间：7 February 2017
• 年：2017
• 卷：35
• 期：6
• 页码：916-922
• 全文大小：1073 K
• 卷排序：35

文摘

Nanoliposome adjuvant induced a robust mucosal and systemic response towards an amebiasis antigen. Vaccine induced mucosal IgA inhibited adherence of E. histolytica to target cells in vitro. This adjuvant is compatible with the use of all-trans retinoic acid as a co-adjuvant. The adjuvant showed potential to elicit protective response against E. histolytica.