Structure Elucidation of Fumagillin-Related Natural Products

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• 作者：Halá ; sz ; Judit ; Podá ; nyi ; Benjamin ; Vasvá ; ri-Debreczy ; Lelle ; Szabó ; Anna ; et. al.
• 关键词：conformation ; X-ray diffraction ; NMR ; antiparasitic activity ; amebicidal activity
• 刊名：Tetrahedron
• 出版年：2000
• 出版时间：December 15, 2000
• 年：2000
• 卷：56
• 期：51
• 页码：10081-10085
• 全文大小：121 K

文摘

Fumagillin is currently the only means of treatment of microsporidiosis, which is frequent and fatal in AIDS patients. Results relating to NMR and X-ray crystallographic studies of fumagillin and the structure elucidation of three related compounds are reported. In the main impurity of fumagillin there is an exocyclic double bond instead of the spiroepoxide moiety. The solid-state and solution structures of fumagillin were compared with the conformation of fumagillin complexed to aminopeptidase-2.