A combined dietary chronic toxicity and two-year carcinogenicity study of (2R,4R)-monatin salt in Sprague-Dawley rats
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- 作者：Witty A. Brathwaitea ; witty_brathwaite@cargill.com" class="auth_mail" title="E-mail the corresponding author ; Christine M. Crincolib ; christine_crincoli@cargill.com" class="auth_mail" title="E-mail the corresponding author ; Alex K. Eapenb ; alex_eapen@cargill.com" class="auth_mail" title="E-mail the corresponding author ; Marisa O. Rihnerc ; mrihner@toxregserv.com" class="auth_mail" title="E-mail the corresponding author ; Andrey I. Nikiforovc ; anikiforov@toxregserv.com" class="auth_mail" title="E-mail the corresponding author ; Amera K. Remickd ; amera.remick@wilresearch.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Carcinogenicity ; Chronic ; Rat ; Safety ; Dietary ; (2R ; 4R)-Monatin
- 刊名：Food and Chemical Toxicology
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：91
- 期：Complete
- 页码：202-216
- 全文大小：3298 K
文摘
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R,R-Monatin was tested in a combined one-year chronic toxicity and two-year carcinogenicity study in Sprague–Dawley rats.
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R,R-Monatin was offered ad libitum in the diet of Sprague–Dawley rats at 0, 5000, 20,000, or 40,000 ppm.
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Long-term ingestion of R,R-monatin (up to two years) resulted in significant effects predominantly on the urinary system.
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No evidence of carcinogenicity was detected in rats fed R,R-monatin in the diet for up to two years.
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The NOAEL was considered 20,000 ppm for the chronic toxicity phase and 5000 ppm for the carcinogenicity phase.