Chronic Myeloid Leukemia with a Rare Variant Philadelphia Translocation: t(9;22;21)(q34;q11;q22)

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• 作者：Guillaume ; Benoî ; t ; Ameye ; Genevi&egrave ; ve ; Libouton ; Jeanne-Marie ; Dierlamm ; Judith ; et. al.
• 刊名：Cancer Genetics and Cytogenetics
• 出版年：2000
• 出版时间：January 15, 2000
• 年：2000
• 卷：116
• 期：2
• 页码：166-169
• 全文大小：1.30 M

文摘

A case of chronic myeloid leukemia displaying an uncommon t(21;22)(q22;q11) is reported. For the first time, this translocation has been characterized by fluorescence in situ hybridization (FISH) and the reverse transcriptase polymerase chain reaction (RT-PCR). FISH, with the use of whole-chromosome painting probes and probes specific for the BCR and ABL genes, showed a three-way variant Philadelphia translocation (9;22;21)(q34;q11;q22) with a BCR/ABL fusion residing on the der(22). In addition, RT-PCR demonstrated a b2a3 BCR/ABL fusion transcript. Underlying mechanisms and prognostic implications are discussed.