The radioenhancement of two human head and neck squamous cell carcinomas by 2′-2′ difluorodeoxycytidine (gemcitabine; dFdC) is mediated by an increase in radiation-induced residual chromos
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- 作者：Rosier ; Jean-Franç ; ois ; Michaux ; Lucienne ; Ameye ; Geneviè ; ve ; Cedervall ; Bjö ; rn ; et. al.
- 关键词：Gemcitabine ; PFGE ; FISH ; DNA DSB ; Chromosome aberrations
- 刊名：Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
- 出版年：2003
- 出版时间：June 19, 2003
- 年：2003
- 卷：527
- 期：1-2
- 页码：15-26
- 全文大小：135 K
文摘
Purpose: The present study aimed at investigating if 2′-2′ difluorodeoxycytidine (dFdC) radioenhancement was mediated by an effect on induction and/or repair of radiation-induced DNA DSBs and chromosome aberrations in cells with different intrinsic radiosensitivity.