Anti-TNF-α and anti-arthritic effect of patuletin: A rare flavonoid from Tagetes patula
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- 作者：Almas Jabeena ; 1 ; almas79_jabeen@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; M. Ahmed Mesaika ; b ; 1 ; mmesaik@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Shabana U. Simjeec ; sh01us@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Lubnac ; lubnazaheer_789@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Samina Banoc ; saminabano786@hotmail.com" class="auth_mail" title="E-mail the corresponding author ; Shaheen Faizic ; shaheenfaizi@hotmail.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：RA ; rheumatoid arthritis ; TNF ; tumor necrosis factor ; NO ; nitric oxide ; IL ; interleukin ; ROS ; reactive oxygen species ; AIA ; adjuvant induced arthritis ; MMP ; matrix metalloproteinase ; PMNs ; polymorphonuclear cells ; PO ; peroxide ; RF ; rheumatoid factor ; SD ; Sprague Dawley ; NF-κB ; nuclear factor kappa B ; AP-1 ; activator protein 1 ; iNOS ; inducible nitric oxide synthase ; COX ; cyclooxygenase ; MAPK ; mitogen associated protein kinase ; JNK ; c-Jun N-terminal kinases ; ERK ; extracellular signal regulated kin
- 刊名：International Immunopharmacology
- 出版年：2016
- 出版时间：July 2016
- 年：2016
- 卷：36
- 期：Complete
- 页码：232-240
- 全文大小：1366 K
文摘
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Patuletin, a flavonoid from Tagetes patula is found to be potent inhibitor of TNF-α.
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Patuletin showed anti-arthritic potential in AIA model of rats.
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Patuletin attenuates inflammatory responses and have immunosuppressive potential.