Efficacy and toxicity of plasmonic photothermal therapy (PPTT) using gold nanorods (GNRs) against mammary tumors in dogs and cats

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• 作者：Ahmed S. Abdoon ; DVM ; PhD^a ; ^{assabdoon@yahoo.com" class="auth_mail" title="E-mail the corresponding author} ; Emad A. Al-Ashkar ; PhD^b ; Omaima M. Kandil ; DVM ; PhD^a ; Ahmed M. Shaban ; PhD^c ; Hussein M. Khaled ; MD^d ; Mostafa A. El Sayed ; PhD^e ; Marwa M. El Shaer ; MD^f ; Asharaf H. Shaalan ; MD^g ; Wael H. Eisa ; PhD^b ; Amina A. Gamal Eldin ; MD^f ; Hany A. Hussein ; DVM ; PhD^a ; Mohammad R. El Ashkar ; DVM^h ; Moustafa R. Ali ; MSc^e ; Ali A. Shabaka ; PhD^b
• 关键词：Dogs and cats ; Mammary tumors ; Gold nanorods ; Near infra-red light ; Cytotoxicity ; Toxicity
• 刊名：Nanomedicine: Nanotechnology, Biology and Medicine
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：12
• 期：8
• 页码：2291-2297
• 全文大小：958 K

文摘

Plasmonic photothermal therapy (PPTT) was introduced as a promising treatment of cancer. This work was conducted to evaluate the cytotoxic effect of intratumoral (IT) injection of 75 μg gold nanorods (GNRs)/kg of body weight followed by direct exposure to 2 w/cm² near infra-red laser light for 10 min on ablation of mammary tumor in 10 dogs and 6 cats. Complete blood count (CBC), liver and kidney function were checked before the start of treatment and one month after injection of GNRs. Results showed that 62.5% (10/16), 25% (4/16) and 12.5% (2/16) of treated animals showed complete remission, partial remission and no response, respectively. Tumor was relapsed in 4 cases of initially responding animals (25%). Overall survival rate was extended to 315.5 ± 20.5 days. GNRs have no toxic effect on blood profile, liver or kidney functions. In conclusion, GNRs can be safely used for treatment of mammary tumors in dogs and cats.