A case study in flux balance analysis: Lysine, a cephamycin C precursor, can also increase clavulanic acid production
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- 作者：André ; Pastrelo Cavallieri ; cavallieri@iq.unesp.br" class="auth_mail" title="E-mail the corresponding author ; Amanda Salvador Baptista asalvadorbaptista@iq.unesp.br" class="auth_mail" title="E-mail the corresponding author ; Carla André ; a Leite carlaandrealeite@iq.unesp.br" class="auth_mail" title="E-mail the corresponding author ; Maria Lucia Gonsales da Costa Araujo mlaraujo@iq.unesp.br" class="auth_mail" title="E-mail the corresponding author
- 关键词：ACV ; aminoadipyl-cysteinyl-valine tripeptide ; C ; carbon ; CA ; clavulanic acid ; CAT ; cadaverine aminotranferase ; ccar ; clavulanic acid cluster regulator ; CephC ; cephamycin C ; FBA ; flux balance analysis ; KLys ; monod constant for lysine for growth on lysine ; KLys1 ; megee constant for lysine for growth on maltose plus lysine ; KMalt ; monod constant for maltose for growth on maltose ; KMalt1 ; megee constant for maltose for growth on maltose plus lysine ; LAT ; lysine aminotransferase ; mLys ; maintenance en
- 刊名：Biochemical Engineering Journal
- 出版年：2016
- 出版时间：15 August 2016
- 年：2016
- 卷：112
- 期：Complete
- 页码：42-53
- 全文大小：1552 K
文摘
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Streptomyces clavuligerus produces Cephamycin C and Clavulanic acid concomitantly.
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In this paper was evaluated concomitant production of these two bioactives by FBA.
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Lysine is a Cephamycin C precursor.
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Lysine combined with maltose favored Clavulanic acid production.
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It was possible to propose a mechanism for this behavior by means of flux analysis.