Development of polymer-supported chiral aminoalcohols derived from biomass and their application to asymmetric alkylation

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• 作者：Marí ; a C. Botta ; Herná ; n D. Biava ; Rolando A. Spanevello ; Ernesto G. Mata ; Alejandra G. Suá ; rez ; ^{suarez@iquir-conicet.gov.ar" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Levoglucosenone ; 1 ; 2-Aminoalcohols ; Chiral ligands ; Asymmetric induction ; Solid-phase synthesis
• 刊名：Tetrahedron Letters
• 出版年：2016
• 出版时间：18 May 2016
• 年：2016
• 卷：57
• 期：20
• 页码：2186-2189
• 全文大小：454 K

文摘

A synthetic strategy has been developed for the preparation of immobilized 1,2-aminoalcohols starting from easily available and renewable chiral building blocks. They were tested as chiral ligands for the asymmetric diethylzinc addition to carbonyl compounds. Enantioselectivities were comparable to those observed for non-immobilized analogs. These results provide strong evidence for the flexibility of our approach to generate highly valuable supported chiral ligands derived from cellulose-rich materials.