Anti-estrogenic effect of semicarbazide in female zebrafish (Danio rerio) and its potential mechanisms
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- 作者：Miao Yu ; Xiaona Zhang ; Linlin Guo ; Hua Tian ; Wei Wang ; Shaoguo Ru ; rusg@ouc.edu.cn" class="auth_mail" title="E-mail the corresponding author
- 关键词：3β-HSD ; 3beta-hydroxysteroid dehydrogenase ; 17β-HSD ; 17beta-hydroxysteroid dehydrogenase ; cGnRH ; chicken gonadotropin-releasing hormone ; CYP ; cytochrome P450 ; E2 ; 17β-estradiol ; ELISA ; enzyme-linked immunosorbent assay ; ERs ; estrogen receptors ; FSH ; follicle-stimulating hormone ; FSHβ ; follicle-stimulating hormone beta subunit ; FSHR ; follicle-stimulating hormone receptor ; GABA ; gamma-aminobutyric acid ; GABAa ; GABA A receptor ; GABAb ; GABA B receptor ; GABA-T ; GABA transaminase ; GAD ; glutamic acid d
- 刊名：Aquatic Toxicology
- 出版年：2016
- 出版时间：January 2016
- 年：2016
- 卷：170
- 期：Complete
- 页码：262-270
- 全文大小：2408 K
文摘
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Female zebrafish were exposed to semicarbazide for 96 hours or 28 days.
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Semicarbazide exposure reduced plasma 17β-estradiol levels at 96 hour and 28 day.
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Ovarian histology was affected after 28-day semicarbazide exposure.
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Semicarbazide-exposed zebrafish showed altered reproductive gene transcription.
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Semicarbazide exerted an anti-estrogenic effect in female zebrafish.