Metabotropic glutamate receptors are involved in the detection of IMP and l-amino acids by mouse taste sensory cells
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- 作者：S. Pal Choudhuri spalchou@uvm.edu" class="auth_mail" title="E-mail the corresponding author ; R.J. Delay rona.delay@uvm.edu" class="auth_mail" title="E-mail the corresponding author ; E.R. Delay ; eugene.delay@uvm.edu" class="auth_mail" title="E-mail the corresponding author ; edelay@uvm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：AIDA ; (RS)-1-aminoindan-1 ; 5-dicarboxylic acid ; Arg ; l-arginine ; CNQX ; cyano-7-nitroquinoxaline-2 ; 3-dione ; CPPG ; (RS)-α-cyclopropyl-4-phosphonophenylglycine ; CTA ; conditioned taste aversion ; d-AP5 ; d-(&minus ; )-2-amino-5-phosphonopentanoic acid ; DHPG ; (S)-3 ; 5-dihydroxyphenylglycine ; GFP ; green fluorescent protein ; GMP ; guanosine 5&prime ; monophosphate ; GPCR ; G-protein-coupled receptor ; HEK cells ; Human Embryonic Kidney cells ; HEPES ; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid ; iGluR ; ionotr
- 刊名：Neuroscience
- 出版年：2016
- 出版时间：1 March 2016
- 年：2016
- 卷：316
- 期：Complete
- 页码：94-108
- 全文大小：1063 K
文摘
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Contrary to theory, taste cells of T1r3 KO mice respond to l-amino acids and IMP.
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10">Selective mGluR1 and mGluR4 agonists activate taste cells of mice.
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15">mGluR1 and mGluR4 antagonists block l-amino acids and IMP responses of T1r3 KO mice.
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Brain and taste variants of mGluR1 and mGluR4 detect l-amino acids and IMP tastes.