Catalyst and solvent-free amidation of inactive esters of N-protected amino acids

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• 作者：Krishna Chaitanya Nadimpally^a ; Kishore Thalluri^a ; Nani Babu Palakurthy^a ; Abhijit Saha^a ; Bhubaneswar Mandal ; ^a ; ^{bmandal@iitg.ernet.in}
• 关键词：Aminolysis ; Inactive esters ; Amino acid ; Amidation
• 刊名：Tetrahedron Letters
• 出版年：2011
• 出版时间：18 May 2011
• 年：2011
• 卷：52
• 期：20
• 页码：2579-2582
• 全文大小：289 K

文摘

A catalyst free procedure for the preparation of amides from inactive esters of N-protected amino acids and various amines is demonstrated under mild reaction conditions. Our effort to recover excess amine and generated alcohol is an approach towards environment friendly and cost effective synthesis under easy operational conditions.