Mild and direct conversion of esters to morpholine amides using diisobutyl(morpholino)aluminum: application to efficient one-pot synthesis of ketones and aldehydes from esters

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• 作者：Ah Ram Jeon ; Min Eai Kim ; Jae Kyo Park ; Won Kyu Shin ; Duk Keun An ; ^{dkan@kangwon.ac.kr" class="auth_mail}
• 关键词：Morpholine amide ; Diisobutyl(morpholino)aluminum ; Ester ; Ketone ; Aldehyde
• 刊名：Tetrahedron
• 出版年：22 July 2014
• 年：2014
• 卷：70
• 期：29
• 页码：4420-4424
• 全文大小：2990 K

文摘

Morpholine amide intermediates, which are easily prepared by aminolysis of various esters with diisobutyl(morpholino)aluminum, react with organolithium and reducing agents (DIBALH or LDBMA) without isolation of the aminolysis intermediates to give ketones in 83–95% yields and aldehydes quantitatively.