Chemoenzymatic arabinosylation of 2-aminopurines bearing the chiral fragment of 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines

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• 作者：Barbara Z. Eletskaya^a ; Irina D. Konstantinova^a ; Alexander S. Paramonov^a ; Roman S. Esipov^a ; Dmitry A. Gruzdev^b ; Alexey Yu. Vigorov^b ; Galina L. Levit^b ; Anatoly I. Miroshnikov^a ; Victor P. Krasnov^b ; ^{ca@ios.uran.ru" class="auth_mail" title="E-mail the corresponding author} ; Valery N. Charushin^b
• 刊名：Mendeleev Communications
• 出版年：2016
• 出版时间：January-February 2016
• 年：2016
• 卷：26
• 期：1
• 页码：6-8
• 全文大小：260 K

文摘

Chemoenzymatic transglycosylation of 2-aminopurine conjugates with enantiomerically pure 7,8-difluoro-3-methyl-3,4-dihydro-2H-[1,4]benzoxazines under the action of recombinant E. coli purine nucleoside phosphorylase afforded the corresponding arabinofuranosides, yields of the target compounds being dependent on both the structure and configuration of the fragment of heterocyclic amine attached at C-6 position of purine moiety.