Microwave-assisted and iodine mediated synthesis of 5-n-alkyl-cycloalkane[d]-pyrazolo[3,4-b]pyridines from 5-aminopyrazoles and cyclic ketones

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• 作者：Jaime Gá ; lvez ; Jairo Quiroga ; ^{jairo.quiroga@correounivalle.edu.co" class="auth_mail} ; Braulio Insuasty ; Rodrigo Abonia
• 关键词：5-Aminopyrazoles ; Microwave irradiation ; Cycloalkanones ; Solvent-free reactions ; Cycloalkanepyrazolopyridines
• 刊名：Tetrahedron Letters
• 出版年：19 March, 2014
• 年：2014
• 卷：55
• 期：12
• 页码：1998-2002
• 全文大小：3825 K

文摘

5-n-Alkylcycloalkane[d]pyrazolo[3,4-b]pyridines were prepared by a microwave-assisted cyclocondensation reaction between 5-aminopyrazoles and cyclic ketones under solvent-free conditions and catalyzed by iodine. This procedure provides a simple one-step and environmentally friendly methodology with good yields for the synthesis of these compounds.