Multiple approaches to assess fourteen non-invasive serum indexes for the diagnosis of liver fibrosis in chronic hepatitis C patients
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- 作者：Marí ; a Jesú ; s André ; s-Oteroa ; Ignacio De-Blas-Giralb ; h ; Juan José ; Puente-Lanzarotea ; g ; Trinidad Serrano-Aulló ; c ; g ; Marí ; a José ; Morandeirad ; g ; Sara Lorentec ; g ; José ; Manuel Lou-Bonafontee ; f ; g ; h ; mlou@unizar.es" class="auth_mail" title="E-mail the corresponding author
- 关键词：HCV ; hepatitis C virus ; AAR ; aspartate alanine aminotransferase ratio ; APRI ; aspartate aminotransferase to platelet ratio index ; GUCI ; Goteborg University Cirrhosis Index score ; FI ; fibrosis index ; FCI ; fibrosis cirrhosis index ; CDS ; cirrhosis discriminant score ; HGM-1 and HGM-2 ; Hospital Gregorio Marañ ; ó ; n ; CHC ; chronic hepatitis C ; MDR-4 ; Modification of Diet in Renal Disease study ; AST ; aspartate aminotransferase ; ALT ; alanine aminotransferase ; UPN ; upper limit of normality ; PTL
- 刊名：Clinical Biochemistry
- 出版年：2016
- 出版时间：May 2016
- 年：2016
- 卷：49
- 期：7-8
- 页码：560-565
- 全文大小：383 K
文摘
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CDS, HGM-2, MODEL3, FI and FCI should be included in an algorithm for diagnosing F = 4.
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The same indexes should be included in an algorithm for identifying advanced fibrosis.
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For diagnosing F ≥ 2, FIB4, GUCI, APRI and HGM-2 are the best indexes.
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A combination of indexes could be used for the diagnosis and follow-up of liver fibrosis stages.
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HGM-2 and FIB4 show very good results for mono-infected CHC patients.