Correlation between the molecular morphology and the biocompatibility of bioadhesive carriers prepared from spray-dried starch/Carbopol^?? blends

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• 作者：Ameye ; Dieter ; Pringels ; Eveline ; Foreman ; Paul ; Remon ; Jean Paul ; Adriaensens ; Peter ; Storme ; Liesbet ; et. al.
• 关键词：Solid state NMR ; Morphology ; Bioadhesion and mucosal irritation
• 刊名：Polymer
• 出版年：2005
• 出版时间：March 10, 2005
• 年：2005
• 卷：46
• 期：7
• 页码：2338-2345
• 全文大小：423 K

文摘

Spray-dried Amioca^® starch/Carbopol^® 974P (C 974P; cross-linked poly(acrylic acid)) blends were evaluated as bioadhesive drug carriers and compared with equivalent physical mixtures. For both mixture types, the nano-morphology was determined by means of SEM and ¹³C-CP/MAS solid state NMR. Whereas phase separation occurs into individual starch and C 974P molecular domains for the physical mixtures, spray-drying results in homogeneous blends of Amioca^® starch and C 974P.

This intimate mixing improves the bioadhesive capacity significantly as compared to equivalent physical mixtures. Up to a 20 wt % content of C 974P, the spray-dried blends did not show any sign of irritation. This makes them promising biocompatible powders for application as safe bioadhesive carriers.