Low levels of vitamin-D are associated with neuropathy and lymphoma among patients with Sj?gren¡¯s syndrome

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• 作者：Nancy Agmon-Levin ; Shaye Kivity ; Athanasios G. Tzioufas ; Marcus L¨®pez Hoyos ; Blaz Rozman ; Inga Efes ; Yinon Shapira ; Ari Shamis ; Howard Amital ; Pierre Youinou ; Yehuda Shoenfeld
• 关键词：Sjö ; gren&rsquo ; s syndrome ; Lymphoma ; Neuropathy ; Vitamin-D ; Autoimmunity
• 刊名：Journal of Autoimmunity
• 出版年：2012
• 出版时间：September, 2012
• 年：2012
• 卷：39
• 期：3
• 页码：234-239
• 全文大小：182 K

文摘

Background/purpose

Primary Sj?gren¡¯s syndrome (SS) is a chronic autoimmune disease primarily involving the exocrine glands. The clinical picture of SS ranges from exocrinopathy to systemic disease affecting the lung, kidney, liver, skin, musculockeletal and nervous systems. The morbidity of SS is mainly determined by extraglandular disease and increased prevalence of lymphoma. Environmental and hormonal factors, such as vitamin-D may play a role in the pathogenic process and disease expression. Thus, we aimed to evaluate levels of vitamin-D and their association with manifestations of?SS.

Methods

Vitamin-D levels were determined in 176 primary SS patients and 163 matched healthy volunteers utilizing the LIAISON chemiluminescent immunoassays (DiaSorin-Italy). A correlation between vitamin-D levels and clinical and serological manifestations of SS was performed.

Results

Mean vitamin-D levels were comparable between SS patients and control 21.2?¡À?9.4?ng/ml and 22.4?¡À?10?ng/ml, respectively. Peripheral neuropathy was diagnosed in 23 % of SS patients and associated with lower vitamin-D levels (18.6?¡À?5.5?ng/ml vs. 22.6¡À8?ng/ml (p?=?0.04)). Lymphoma was diagnosed in 4.3 % of SS patients, who had lower levels of vitamin-D (13.2?¡À?6.25?ng/ml), compared to SS patients without lymphoma (22?¡À?8?ng/ml), (p?=?0.03). Other clinical and serological manifestations did not correlate with vitamin-D status.

Conclusions

In this study, low levels of vitamin-D correlated with the presence of peripheral neuropathy and lymphoma among SS patients. The link between vitamin-D and neuropathy or lymphoma was reported in other conditions, and may support a role for vitamin-D in the pathogenesis of these processes. Plausible beneficial effect for vitamin-D supplementation may thus be suggested.