Non-heat shock responsive roles of HSF1 in Candida albicans are essential under iron deprivation and drug defense

详细信息    查看全文

• 作者：Remya Nair^a ; ^b ; Mohd Shariq^b ; ^c ; Sanjiveeni Dhamgaye^b ; ¹ ; Chinmay K. Mukhopadhyay^c ; Shamim Shaikh^a ; Rajendra Prasad^b ; ^d ; ^{rprasad@ggn.amity.edu} ; ^{rp47jnu@gmail.com}
• 关键词：MDR1 ; Multi drug resistance-1 ; BPS ; Bathophenanthroline disulfonate ; (DOX ; Doxycycline
• 刊名：Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：1864
• 期：2
• 页码：345-354
• 全文大小：1716 K
• 卷排序：1864

文摘

The HSF1 mutant possesses lowered cellular iron pool at 30 °C. The mutant with no growth defect elicits interesting phenotypes at 30°C. HSF1 mutant displays enhanced drug susceptibilities; compromised mitochondrial integrity and cell wall. The HSF1 mutant displays defects in hyphal formation. Chemical iron chelation aggravates HSF1 mutant phenotypes at 30 °C.