Post-extinction selective persistence of large dendritic spines in fear remodeled circuits may serve to reactivate fear
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- 作者：Annabella Pignataro2 ; Martine Ammassari-Teule1 ; 2 ; martine.teule@cnr.it" class="auth_mail" title="E-mail the corresponding author
- 刊名：Current Opinion in Neurobiology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：35
- 期：Complete
- 页码：1-5
- 全文大小：395 K
文摘
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Fear memory formation increases the number and the size of dendritic spines in fear-activated brain regions.
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Fear extinction resets the density but not the size of spines to baseline levels.
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Degradation of the extra cellular matrix into the basolateral amygdala prevents fear memory reactivation and disrupts post-extinction persistence of spine enlargement.
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Persistence of memory-driven large spines is needed to reactivate fear memory.