Reactions of Quaternary Ammonium Salt Having a Polyfluoroalkenyl Group with Secondary Amines. A New Convenient and Stereoselective Synthesis of β-Trifluoromethylated Enamines

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• 作者：Yamanaka ; Hiroki ; Shiomi ; Keisuke ; Ishihara ; Takashi
• 刊名：Tetrahedron Letters
• 出版年：1995
• 出版时间：October 2, 1995
• 年：1995
• 卷：36
• 期：40
• 页码：7267-7270
• 全文大小：235 K

文摘

Trimethyl-[(Z)-2,3,3,3-tetrafluoro-1-propenyl]ammonium iodide (1) easily liberated methyl iodide at 70 °C in an aprotic polar solvent to generate quantitatively N,N-dimethyl-[(Z)-2,3,3,3-tetrafluoro-1-propenyl]amine (2a), which underwent the N-N exchange reaction with secondary amines, leading stereoselectively to the corresponding N,N-dialkyl-[(Z)-2,3,3,3-tetrafluoro-1-propenyl]amines (2b-k) in good yields.